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Life Sciences Stellen Basel
EDP 25 Jahre Jubiläum

Analytical Scientist (m/f/d), 100% (temporary)

Temporärstelle
Einritt: 01.10.2021
Stelle: Life Sciences
Art: Temporärstelle

You are interested in understanding complex materials, in applying an interdisciplinary scientific approach for their investigation and you can work well in a team. Hands-on experience with chromatographic characterization techniques (SEC and SEC combined with multi-detection systems) as well as a basic understanding of viscosity are important for the project

01.10.2021

#AnalyticalChemistry #GMP #Pharma

Our customer, a pharmaceutical company based in Basel, needs reinforcement. For a temporary employment (01.10.2021 until 30.09.2022, with option for extension), we are looking for a

Analytical Scientist (m/f/d), 100% (temporary)

Major accountabilities:

  • Physical chemical characterization of polymers and drug products by various characterization techniques (e.g. size exclusion chromatography (SEC), HPLC, viscometers) with the aim of optimizing parameters like drug loading capacity, stability under storage or biologic conditions, effects of molecular structure (e.g. star architecture) on degradation and drug release profile
  • Method development with the use of SEC combined with multi-detection system (e.g. ultraviolet (UV), differential refractive index (RI), viscosity, multi-angle light scattering (MALS)) to characterize the absolute molar-mass averages (Mn and Mw), molar-mass distribution (described by the dispersity), the radius of gyration (Rg), the hydrodynamic radius (Rh), and the subsequent conformation of macromolecules
  • Set up of SEC-MALS methodology and of data analysis to elucidate the role of molecular structure in drug loading and release
  • Perform routine viscosity tests (e.g. viscosity and flow curves, dynamic viscosity measurements) by various methods (rotational viscometer, Höppler, DIN 53015 and ISO 12058 based on falling ball measuring principle) and at the occurrence support as deputy images acquisition of drug products by optical microscopy
  • Write and follow laboratory documentation (e.g. SOPs), maintain accurate records and GMP documentation
  • Activities include supporting product development and depending on projects, also GMP analyses for release, stability and clinical studies
  • Enter data in LIMS system and report the results in clear analytical reports
  • Operate and maintain testing equipment (GMP and not). Troubleshoot and perform preventive maintenance on equipment (GxP and not) and/or coordinate maintenance through equipment vendors

Background:

  • Postgraduate, preferentially with a completed Master in analytical chemistry, or related disciplines
  • Strong background and experience in size exclusion chromatography (SEC, SEC-MALS)
  • Sound Knowledge of data generation and processing
  • Ability to resume analytical results in well-structured written reports
  • Problem solving mindset: anticipating issues and proactively finding solutions independently
  • Able to work with people effectively at all levels in international and multidisciplinary teams
  • Previous experience in similar industry (e.g. pharma, food, al.) and in GMP are a plus
  • Proficient in English, any other language skill is welcome

For questions

… please contact Mr. Renato Imboden by phone on 061 269 90 60

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